Expression of cathepsin K and matrix metalloproteinase 1 indicate persistent osteodestructive activity in long-standing ankylosing spondylitis
نویسندگان
چکیده
منابع مشابه
Urolithiasis in ankylosing spondylitis: Correlation with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI)
Background: Increased incidence of renal stone has been reported in ankylosing spondylitis (AS), but unlike some well-known renal involvements, they have not been fully studied. The aim of this study was to investigate the association of AS with urolithiasis and also the relation between urinary stone and severity markers. Methods: One hundred-sixty three AS patients were included in a cross-s...
متن کاملAssociation of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis
INTRODUCTION The pathology of ankylosing spondylitis (AS) suggests that certain cytokines and matrix metalloproteinases (MMPs) might provide useful markers of disease activity. Serum levels of some cytokines and MMPs have been found to be elevated in active disease, but there is a general lack of information about biomarker profiles in AS and how these are related to disease activity and functi...
متن کاملTransverse myelitis in a patient with long-standing ankylosing spondylitis.
Ankylosing spondylitis is reported to involve not only the joints but other organs as well. Among these extra-articular involvements, uncommon complications associated with nervous system such as single root lesions, compression of the myelum and cauda equina syndrome have also been documented. Here we present a patient with long-standing ankylosing spondylitis who developed spastic paraparesis...
متن کاملCT of long-standing ankylosing spondylitis with cauda equina syndrome.
The authors present distinctive computed tomographic (CT) findings in two cases of long-standing ankylosing spondylitis accompanied by the cauda equina syndrome. Multiple, asymmetric erosions of the posterior elements of the lumbar spine on CT were correlated with thecal diverticula demonstrated by myelography. The pathogenesis of these erosions may be related to arachnoiditis in the early phas...
متن کاملExpression of Matrix Metalloproteinase-2 and -9 in Meningioma
Background: Meningioma is one of the most common tumors of the central nervous system. It was shown that meningioma had up-regulated expression of Matrix Metalloproteinases (MMPs) that involved in cell growth, angiogenesis and metastasis. Objectives: The aim of the study was the assessment of serum MMP-2 and -9 levels in patients with different grades of meningioma. Materials & Me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2008
ISSN: 0003-4967
DOI: 10.1136/ard.2008.092494